I've been playing PyGTK 2.22 for a while now, and I think it could make its way into next MyPaint, no more major bugs (of user interface) as far as I know and windows theme bugfixes already there. Finally a real successor of 2.16.x version after skipping 2.18 and 2.20
I'd like to see PyGTK team build this version with Numpy support though, but if not I will uploaded it here. Still waiting official binary...
Ah and the answer is absolutely NO, it turn out that pressure sensitive tablet has problem
gtk.Recentdocument assertion failed... my my I'm a bad tester am I? Folks of linux said it has something to do with specific Icon Theme! Well gtk win32 doesn't even have such! what should I do then? :)